Could you explain how (that is, which bit of) the EG molecule fits the ADH active site? And would it be the same for PG? And what about ethanol, for which, I believe, ADH has a much higher affinity? Sorry, a man's got to know his limitations. The Wikipedia article on alcohol dehydrogenase(s) looks good, and there's probably a graphic somewhere.... Only one general thought to add: the difference between ethylene glycol and propylene glycol doesn't produce very different chemical properties, but enzymes are designed to be sensitive to shape and size. There are a couple of fascinating clinical examples: Pseudocholinesterase deficiency, which probably affects at least one Member although he probably doesn't know. This can produce what's supposed to be one of the most terrifying experiences: consciousness with muscle blockade. And it's familial, so great for thrillers. Medium-chain acyl dehydrogenase deficiency. Probably the only population screening programme for a condition which most doctors have never heard of, let alone seen. But there'll be more along soon... Jonathan